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Wrestled with this problem yesterday and I've got it working, here's a few things to check for (given that you're activated):

-If you're using enso+sd2vita: make sure your config.txt on ux0 has either been deleted and/or transferred over onto ur0.

-make sure your config.txt is formatted correctly

-The easyinstaller sometimes fudges the config.txt after you've installed/reinstalled multiple times, so delete any duplicate lines or empty spaces that may be in there. (Note that the line beneath *KERNEL should be directing to the .skprx file, NOT the .suprx. There should be a separate *TITLEID entry below that that directs to the .suprx. Don't know how that could get mixed up, but somehow i made that possible)

-again, for enso+sd2vita users: the gamesd line in the config.txt MUST come before the line directing to adrenaline, so: *KERNEL ur0:tai/gamesd.skprx ur0:adrenaline/adrenaline.skprx

That's all I got off the top of my head. If nothing seems to be working, try reinstalling Enso and reinstalling adrenaline from scratch. That may magically fix something, but usually something is wrong with your config.txt